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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TMPO All Species: 13.94
Human Site: S458 Identified Species: 38.33
UniProt: P42166 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P42166 NP_003267.1 694 75492 S458 I P G S E L M S S F A K T V V
Chimpanzee Pan troglodytes XP_509288 694 75514 S458 I P G S E L M S S F A K T V V
Rhesus Macaque Macaca mulatta XP_001082600 695 75456 P458 I P G S E L L P S S F A K T V
Dog Lupus familis XP_539735 693 75491 S457 T P G S G V M S S F A K T V V
Cat Felis silvestris
Mouse Mus musculus Q61033 693 75313 S456 T P G S E H R S S F A K S V V
Rat Rattus norvegicus Q62733 452 50259 E229 Y S E A G V T E T E W T S G S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006235 446 50163 S223 V T E T V W T S G S S K S G P
Frog Xenopus laevis NP_001079677 206 23473
Zebra Danio Brachydanio rerio NP_851299 657 72198 V434 V S K L S K P V L S Q S K P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 95.8 87.7 N.A. 78.5 36.8 N.A. N.A. 32.7 22.7 25.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.7 97.8 91.7 N.A. 86.5 49.7 N.A. N.A. 46.8 26.9 40.4 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 53.3 80 N.A. 73.3 0 N.A. N.A. 13.3 0 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 60 86.6 N.A. 80 26.6 N.A. N.A. 40 0 6.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 12 0 0 0 0 0 0 45 12 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 23 0 45 0 0 12 0 12 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 45 12 0 0 0 0 % F
% Gly: 0 0 56 0 23 0 0 0 12 0 0 0 0 23 0 % G
% His: 0 0 0 0 0 12 0 0 0 0 0 0 0 0 0 % H
% Ile: 34 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 12 0 0 12 0 0 0 0 0 56 23 0 0 % K
% Leu: 0 0 0 12 0 34 12 0 12 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 34 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 56 0 0 0 0 12 12 0 0 0 0 0 12 12 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 12 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % R
% Ser: 0 23 0 56 12 0 0 56 56 34 12 12 34 0 23 % S
% Thr: 23 12 0 12 0 0 23 0 12 0 0 12 34 12 0 % T
% Val: 23 0 0 0 12 23 0 12 0 0 0 0 0 45 56 % V
% Trp: 0 0 0 0 0 12 0 0 0 0 12 0 0 0 0 % W
% Tyr: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _